The Cardinals entered the night in Lexington facing a 2-0 deficit after early strikes from Michael Lee and Yasha Schaerer, but the team refused to fold.
A Late Surge in Lexington
Zizza found the net twice, the second coming in the eighth minute of extra time, sealing a 3-2 result and marking his second goal of the match.
Earlier, Louisville had narrowed the gap with a penalty converted by Andres Escuerdo in the 56th minute, shifting momentum and forcing the game into sudden death.
The win extends Louisville's unbeaten streak against Kentucky to four straight meetings and improves their season record to two victories, while Kentucky's perfect start is snapped.
Next up, the Cardinals travel to face Lipscomb on Thursday at 6 p.m. ET before a showdown with Indiana on August 31.