The tenth week of the 2026 college football season delivers a slate of marquee contests that could reshape the playoff picture. From the Pacific Northwest to the Deep South, top‑ranked teams are set to collide in games that carry both conference and national implications.
The Oregon Ducks will hit the road to take on the Ohio State Buckeyes, reviving a rivalry that last met in a College Football Playoff quarterfinal at the Rose Bowl two seasons ago. Oregon opened a 32‑31 victory over the Buckeyes at Autzen Stadium in 2021, and the Ducks enter the matchup with a top‑five ranking and fifth‑best national title odds at +800.
A Historic Rivalry Returns
Ohio State, meanwhile, boasts the best odds at +650 according to DraftKings Sportsbook and is expected to be among the top three teams. A win for the Buckeyes would not only bolster their playoff résumé but also avenge a regular‑season loss that still haunts the program.
In the Midwest, the Miami Hurricanes travel to face the Notre Dame Fighting Irish in a rematch of last season’s thriller that decided the final playoff spot. Miami’s recent national‑championship runner‑up status and a 2025 win over the Irish add extra stakes to the night‑time showdown.
Alabama’s Crimson Tide meet LSU’s Tigers in a clash of programs that have dominated the past two decades. LSU’s new head coach Lane Kiffin promises a fresh approach, and a night game at Tiger Stadium is expected to generate an electric atmosphere.
The Georgia Bulldogs and Ole Miss Rebels will meet again after a dramatic Sugar Bowl encounter last season in which Ole Miss stunned the Bulldogs. Georgia, still seeking its first playoff win since the 2022 national championship, will look to reclaim supremacy.
With multiple top‑ten teams in action and betting markets already reflecting the uncertainty, the outcomes of these games will likely dictate the final rankings and could set up a cascade of changes as the season hurtles toward its climax.